3-Methoxypropylamine → N-(3-Methoxypropyl)-6-[[1-(4-methylphenyl)-2-benzylmercapto-1H-benzimidazol-6-yl]oxy]Hexanamide

HRID 1070857Notes

Reaction equation

HRID 1070857 reaction equation
CO[C:3](=[O:34])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[CH:12][C:13]2[N:17]=[C:16]([S:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[N:15]([C:26]3[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][CH:27]=3)[C:14]=2[CH:33]=1.[CH3:35][O:36][CH2:37][CH2:38][CH2:39][NH2:40]>>[CH3:35][O:36][CH2:37][CH2:38][CH2:39][NH:40][C:3](=[O:34])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[CH:12][C:13]2[N:17]=[C:16]([S:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[N:15]([C:26]3[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][CH:27]=3)[C:14]=2[CH:33]=1

Participants

3

Reactant 2

HCID 16723-MethoxypropylamineHCID 101625126-[[2-Benzylmercapto-1-(4-methylphenyl)-1H-benzimidazol-6-yl]oxy]Hexanoic Acid Methyl Ester

Product 1

HCID 69438142N-(3-Methoxypropyl)-6-[[1-(4-methylphenyl)-2-benzylmercapto-1H-benzimidazol-6-yl]oxy]Hexanamide

Procedure

100 mg of 6-[[2-benzylmercapto-1-(4-methylphenyl)-1H-benzimidazol-6-yl]oxy]hexanoic acid methyl ester was reacted with 3-methoxypropylamine according to general operating instructions 4. 53 mg was obtained.

Workup

  1. custom53 mg was obtained

Sources & evidence

ORD record
ord-875bb44c75a442d497203d8892446fb1
Source dataset
uspto-grants-2005_06
Patent number
US06903126B2

Reaction notes

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