Morpholine → 6-[[2-(Morpholin-4-yl)-1-phenyl-1H-benzimidazol-6-yl]oxy]Hexanoic Acid Methyl Ester

関与物質

反応条件

反応手順

657 mg of 6-[[2-chloro-1-phenyl-1H-benzimidazol-6-yl]oxy]hexanoic acid methyl ester was dissolved in 13 ml of morpholine, and the mixture was stirred for 6 hours at 120° C. It was concentrated by evaporation to a very large extent in a vacuum, mixed with water, extracted with ethyl acetate, the organic phase was dried on sodium sulfate and concentrated by evaporation in a vacuum. The residue was purified by column chromatography on silica gel. 271 mg was obtained.

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