関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | Dicyclohexano-18-crown-6 | HCID 85955 | — |
| 反応物 | Potassium Bicarbonate | HCID 516893 | — |
| 反応物 | HCID 178500329 | HCID 178500329 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 6-[(2-Benzylmercapto-1-phenyl-1H-benzimidazol-6-yl)oxy]Hexanoic Acid Methyl Ester | HCID 69431600 | — |
反応手順
490 mg of 6-[(2-mercapto-1-phenyl-1H-benzimidazol-6-yl)oxy]hexanoic acid methyl ester was dissolved in 7 ml of N,N-dimethylformamide, mixed with 0.19 ml of benzyl bromide, 278 mg of potassium bicarbonate and 49 mg of dicyclohexano-18-crown-6, and the mixture was stirred for 15 hours at 20° C. It was filtered, and the filtrate was concentrated by evaporation in a vacuum. The residue was purified by column chromatography on silica gel. 548 mg was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06903126B2 |
|---|
| 出典データセット | uspto-grants-2005_06 |
|---|
| ORD ID | ord-b23502d5a8bc41d09c75a246a5547e42 |
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| 出典メモ | uspto-grants-2005_06 |
|---|
