Miridesap → HCID 69463152, compound

Participants

Reaction Steps

A mixture of 2.04 g (6 mmol) (R)-1-[6-[(R)-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl]-pyrrolidine-2-carboxylic acid and 5 g Amberlite® IR120 in 25 ml 4-penten-1-ol were stirred at room temperature for 48 hours. After filtration the solvent was distilled off, the residue was taken up in dichloromethane and extracted with 2% aqueous sodium bicarbonate. The organic extract was dried with sodium sulfate and the solvent was distilled off to yield 1.6 g (58%) (R)-1-[6-[(R)-2-pent-4-enyloxycarbonyl-pyrrolidin-1-yl]-6-oxo-hexanoyl]-pyrrolidine-2-carboxylic acid pent-4-enyl ester as a light yellow oil, MS m/e (%): 477 (M+H+, 100).

Provenance & Evidence