HuagongsheHuagongshe Chemistry Print Report · For research reference only
Atropic acid → 3-[4-(Tert-butoxycarbonyl)piperazino]-2-phenylpropanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Atropic acid | HCID 68114 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 3-[4-(Tert-butoxycarbonyl)piperazino]-2-phenylpropanoic acid | HCID 45588421 | 54.3% |
Reaction Steps
Piperazine-1-carboxylic acid tert-butyl ester (17.43 g) and 2-phenylacrylic acid (18 g) in iso-propanol (500 ml) was heated at reflux for four days. The resulting precipitate was filtered, washed with diethyl ether and dried under vacuum to give the title compound as a white solid (17 g; MS: APCI+(M+H) 335).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06903115B2 |
| Source dataset | uspto-grants-2005_06 |
| ORD ID | ord-313c7265bfbe4cfba0109009e5c13020 |
| Source note | uspto-grants-2005_06 |