Methanol → Methyl 4-hydroxypiperidine-4-carboxylate

HRID 107095Notes

Reaction equation

HRID 107095 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][C:11]([C:14](=[O:15])[O:16][CH3:17])([OH:18])[CH2:12][CH2:13]1.[CH3:19][OH:20].[OH-:21].[OH-:22].[Pd+2:23]>>[NH:8]1[CH2:9][CH2:10][C:11]([C:14](=[O:15])[O:16][CH3:17])([OH:18])[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 12343427Methyl 1-benzyl-4-hydroxypiperidine-4-carboxylate

Product 1

HCID 21093366Methyl 4-hydroxypiperidine-4-carboxylate

Sources & evidence

ORD record
ord-da5cb57622b540098b574600ddb244c6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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