HCID 20798322, compound → HCID 20798321, compound

HRID 1071168Notes

Reaction equation

HRID 1071168 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[O:10][CH:9]([C:14]([NH2:16])=[O:15])[CH2:8][CH2:7]2)([O-])=O>[Pd].C(O)C>[NH2:1][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[O:10][CH:9]([C:14]([NH2:16])=[O:15])[CH2:8][CH2:7]2

Participants

4

Reactant 1

HCID 20798322HCID 20798322, compound

Product 1

HCID 20798321HCID 20798321, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of compound from example 61 (6.75 g, 30.0 mmol), absolute ethanol (700 mL) and 10% activated palladium on carbon (1.35 g) was placed under a hydrogen balloon for 24 h. The product was filtered through celite and the solvent was evaporated to afford the title compound (5.76 g, 100%). Rf=0.4 (methylene chloride:methanol 95:5); MS (FAB) m/z 193 (MH+).

Workup

  1. customfor 24 h
  2. filtrationThe product was filtered through celite
  3. customthe solvent was evaporated

Sources & evidence

ORD record
ord-9ee130cc16b7481c8211aab2e75d5cec
Source dataset
uspto-grants-2005_06
Patent number
US06903218B2

Reaction notes

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