Hydrochloric Acid → HCID 9860275, compound

Participants

Reaction Steps

A mixture of 1.5 g of 6-acetamido-2-cyanomethylchromane (Example 14) in 25 mL of concentrated hydrochloric acid is stirred vigorously at room temperature for about 6 h. Ethanol (50 mL) is added and the mixture allowed to stand overnight. The precipitate is filtered, rinsed with 50-mL aliquots of ether, and dried. Absolute ethanol (25 mL) and HCl (10 mL) are stirred with the precipitate for 2 h, followed by addition of 10 mL of concentrated HCl. The precipitate is recovered and recrystallized twice from ether/isopropanol affording about 1.3 g of ethyl 2-(6-aminochroman-2-yl)acetate hydrochloride (about 80% yield).

Provenance & Evidence