HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1071194Generated: November 1, 2026
Sulfuric Acid → Ethyl 4-oxo-4H-1-benzopyran-2-carboxylate
https://huagongshe.com/reaction/1071194
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Diethyl Oxalate | HCID 7268 | — |
| Reactant | alpha-Hydroxyacetophenone | HCID 68490 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Ethyl 4-oxo-4H-1-benzopyran-2-carboxylate | HCID 26861 | 189.8% |
Reaction Steps
Into a solution of 12.0 g of diethyl oxalate in 180 g of toluene is added 30 g of 2-hydroxyacetophenone, then dropwise added 65.0 g of 20% sodium ethoxide in ethanol. After the reaction is complete, 13 g of 98% sulfuric acid is added, and the mixture stirred at 60° C. for about 30 min. After adding 140 g of water, the organic fraction is separated. The organic fraction is concentrated and 55.0 g of hexane is added. Filtering below 10° C. affords about 34.0 g of ethyl chromone-2-carboxylate (about 95% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06903227B2 |
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| Source dataset | uspto-grants-2005_06 |
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| ORD ID | ord-32a29a9a03ea46e8acef25273299df99 |
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| Source note | uspto-grants-2005_06 |
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