Sulfuric Acid → HCID 15882768, compound

HRID 1071220Notes

Reaction equation

HRID 1071220 reaction equation
N[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:11][CH3:12])[CH:9]=2)[C:4](=[O:13])[C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1.[OH:22]S(O)(=O)=O>>[CH3:12][O:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[C:4](=[O:13])[CH:3]([C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1)[C:2]2=[O:22]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 389548NSC685853

Product 1

HCID 15882768HCID 15882768, compoundYield 99%

Procedure

3-Amino-5-methoxy-2-(4-methoxyphenyl)-1H-inden-1-one (500 mg, 1.78 mmol), was suspended in a solution of 20% H2SO4 and heated to 120° for 1 h. The reaction was allowed to cool and the residual solid filtered and the filter cake was washed copiously with water and dried in vacuo to give a light white solid (0.5 g, 99% yield, m.p. 163° C.);

Workup

  1. temperatureheated to 120° for 1 h
  2. temperatureto cool
  3. filtrationthe residual solid filtered
  4. washthe filter cake was washed copiously with water
  5. customdried in vacuo

Sources & evidence

ORD record
ord-3e0a02d953dd45e1935b01e853bf4b9d
Source dataset
uspto-grants-2005_06
Patent number
US06903238B2

Reaction notes

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