Dimethylformamide → HCID 22472042, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-Bromo-6-methoxy-2-(4-methoxyphenyl)-1H-inden-1-one (150 mg, 0.4345 mmol), sodium ethanethiolate (91.4 mg, 1.09 mmol), and triethyl amine (0.5 ml) in N,N, dimethyl formamide (3 mL) was heated at 80° C. for 24 h. The reaction was cooled to room temperature was poured into water and extracted with ethyl acetate. The organic extracts were washed with brine and were dried over MgSO4. Evaporation and flash chromatography (10% ethyl acetate/petroleum ether) gave (126 mg, 89% yield) of the product as a dark red solid: mp 88-90° C.; MS m/e 327 (M+H)+.

Provenance & Evidence