3-Methoxy-4-o-tolylureidophenylacetic acid → HCID 22398051, compound

HRID 1071288Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:20][C:21]([OH:23])=O)[CH:6]=[CH:7][C:8]=1[NH:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH3:19])=[O:11].Cl.C[O:26][C:27](=[O:52])[CH:28]([NH:41][C:42](=[O:51])[C:43]1[C:48]([Cl:49])=[CH:47][CH:46]=[CH:45][C:44]=1[Cl:50])[CH2:29][C:30]1[O:34][N:33]=[C:32]([CH:35]([NH2:40])[CH2:36][CH:37]([CH3:39])[CH3:38])[CH:31]=1>>[Cl:50][C:44]1[CH:45]=[CH:46][CH:47]=[C:48]([Cl:49])[C:43]=1[C:42]([NH:41][CH:28]([CH2:29][C:30]1[O:34][N:33]=[C:32]([CH:35]([NH:40][C:21](=[O:23])[CH2:20][C:5]2[CH:6]=[CH:7][C:8]([NH:9][C:10]([NH:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[CH3:19])=[O:11])=[C:3]([O:2][CH3:1])[CH:4]=2)[CH2:36][CH:37]([CH3:39])[CH3:38])[CH:31]=1)[C:27]([OH:52])=[O:26])=[O:51]

Participants

Reactant 2

HCID 114498403-Methoxy-4-o-tolylureidophenylacetic acid

HCID 69735661HCID 69735661, compound2×

Product 1

HCID 22398051HCID 22398051, compoundYield 51%

Procedure

The title compound was prepared in the manner described in example 2B using 3-methoxy-4-(3-o-tolyl-ureido)-phenylacetic acid and 3-[3-(1-amino-3-methyl-butyl)-isoxazol-5-yl]-2-(2,6-dichloro-benzoylamino)-propionic acid methyl ester hydrochloride. 51% yield; white solid. MS (m/z) 724.2 and 726.2 (M+1). C. 3-[3-(1-Amino-3-methyl-butyl)-isoxazol-5-yl]-2-(2,6-dichloro-benzoylamino)-propionic acid methyl ester hydrochloride

Sources & evidence

ORD record: ord-66a20ca8296a4dd1a9b835cccc2f884b
Source dataset: uspto-grants-2005_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06903128B2

Reaction notes

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