Hydrochloric Acid → HCID 22034782, compound

Participants

Reaction Steps

A mixture of 5-benzylamino-3-bromo-1-(2′-methoxyethyl)-4-nitropyrazole (4 g, 2.8 mmol) in ethanol (500 ml) comprising a 10% Pd/C catalyst (Johnson-Mattey Type 487, dry weight 0.5 g) and 36% hydrochloric acid (0.57 g, 5.6 mmol) was hydrogenated in a Parr Autoclave (1 l) at 1 MPa for 1 hour. The catalyst was then removed by filtration and washed with ethanol, and the filtrate was evaporated under reduced pressure. A crude orange-colored solid (2.8 g) was thus obtained, and was triturated in EtOAc (20 ml) for 1 hour. The solid was then filtered off and washed with cold EtOAc (20 ml) and then dried under vacuum to give the 4,5-diamino-1-(2′-methoxyethyl)pyrazole in the form of a beige-colored solid (0.7 g, 27%).

Provenance & Evidence