HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(3-Fluoro-4-methoxybenzoyl)propionic acid → 1-(3-Fluoro-4-methoxyphenyl)-4-((R)-octahydropyrido[1,2-a]pyrazin-2-yl)butane-1,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(3-Fluoro-4-methoxybenzoyl)propionic acid | HCID 67671 | — |
| Reactant | (2R)-1-[(tert-butoxy)carbonyl]piperidine-2-carboxylic acid | HCID 688618 | — |
| Reactant | 1-(3,4-Dimethoxyphenyl)-4-((S)-hexahydropyrrolo[1,2-a]pyrazin-2-yl)butane-1,4-dione | HCID 24886334 | — |
| Product | 1-(3-Fluoro-4-methoxyphenyl)-4-((R)-octahydropyrido[1,2-a]pyrazin-2-yl)butane-1,4-dione | HCID 24886571 | — |
Reaction Steps
93 mg of the title compound were prepared as described for 1-(3,4-dimethoxyphenyl)-4-((S)-hexahydropyrrolo[1,2-a]pyrazin-2-yl)butane-1,4-dione, using (R)-1-(tert-butoxycarbonyl)piperidine 2 carboxylic acid instead of BOC-protected proline and 3-(3-fluoro-4-methoxybenzoyl)propionic acid instead of 3-(3,4-dimethoxybenzoyl)propionic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06906060B2 |
| Source dataset | uspto-grants-2005_06 |
| ORD ID | ord-d04d48979ed94c52aaffb5309c1ceed1 |
| Source note | uspto-grants-2005_06 |