4-[(trimethylsilyl)ethynyl]benzyl tert-butyldiphenylsilyl Ether → 4-[(Z)-(5,5-Dimethyl-8-p-tolyl-5,6-dihydronaphthalen-2-yl)trimethylsilanylvinyl]-benzyl Alcohol

Participants

Reaction Steps

Following General Procedure A, 4-[(trimethylsilyl)ethynyl]benzyl tert-butyldiphenylsilyl ether and 6-bromo-1,1-dimethyl-4-p-tolyl-1,2-dihydronaphthalene (prepared as described in Klein, et al., U.S. Pat. No. 5,952,345) were coupled to give the title compound (Compound 23). PNMR (300 MHz, CDCl3): δ0.13 (s, 9H), 1.47 (s, 6H), 2.48 (d, J=4.4 Hz, 2H), 2.54 (s, 3H), 4.82 (d, J=6.1 Hz, 2H), 6.10 (t, J=4.4 Hz, 1H), 7.00 (d, J=2.2 Hz, 1H), 7.18 (dd, J=2.2, 7.9 Hz, 1H), 7.30-7.45 (m, 10H).

Provenance & Evidence