4-Amino-2-chloropyrimidine-5-carbonitrile → HCID 22393271, compound

Participants

Reaction Steps

A solution of 4-amino-2-chloro-5-cyanopyrimidine (200 mg, 1.3 mmol) and 4-[N-(3-imidazol-1-ylpropyl)carbamoyl]aniline (Method 3; 633 mg, 2.6 mmol) in NMP (10 ml) was heated at 120° C. for 48 hours. The mixture was allowed to cool, was diluted with water and extracted with ethyl acetate. The organic extracts were combined, dried and the solvent removed by evaporation, the residue was triturated with ether/hexane and the product collected by filtration to give the title compound (10 mg, 2%). NMR: 1.92 (q, 2H) 3.20 (q, 2H), 4.00 (t, 2H), 6.87 (s, 1H), 7.19 (s, 1H), 7.55 (s, 2H), 7.62 (s, 1H), 7.86 (d, 2H), 8.32 (t, 1H), 8.38 (s,1H), 9.90 (s, 1H); m/z 363 (MH)+.

Provenance & Evidence