HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloroaniline → 4-Amino-5-cyano-2-(3-chloroanilino)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloroaniline | HCID 7932 | — |
| Reactant | 4-Amino-2-chloropyrimidine-5-carbonitrile | HCID 2801166 | — |
| Product | 4-Amino-5-cyano-2-(3-chloroanilino)pyrimidine | HCID 22393275 | 90% |
Reaction Steps
3-Chloroaniline (277 mg, 2.2 mmol) was treated with 4-amino-2-chloro-5-cyanopyrimidine (0.3 g, 2.0 mmol) by the procedure described in Example 1 to give the title compound (430 mg, 90%). NMR: 7.00 (d, 1H), 7.28 (dd, 1H), 7.55 (s, 2H), 7.70 (d, 1H), 7.89 (s, 1H), 8.38 (s, 1H), 9.81 (s, 1H); m/z 246 (MH)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06906065B2 |
| Source dataset | uspto-grants-2005_06 |
| ORD ID | ord-fde442438e684f9b81693bedf4b35dd4 |
| Source note | uspto-grants-2005_06 |