1,4-Dioxane hydrochloride → HCID 10174216, compound

Participants

Reaction Steps

To a solution of tert-butyl (2S,3S)-3-(3,5-bis(trifluoromethyl)benzyloxymethyl)-4-methyl-5-oxo-2-phenylpiperizine-1-carboxylate (6.5 g, 11.9 mmol) in 1,4-dioxane (100 mL) was added 4 mol/L HCl-1,4-dioxane (15 mL, 59.5 mmol). After stirring at room temperature for 2 hours, the solvent was removed by evaporation under reduced pressure to give (5S,6S)-6-(3,5-bis(trifluoromethyl)benzyloxymethyl)-1-methyl-5-phenylpiperazin-2-one hydrochloride (Compound 24) (5.5 g, 96%).

Provenance & Evidence