HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Hydroxyisobutyric acid → 5-{N'-(2-hydroxy-2-methylpropionyl)-L-alaninyl}-amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Hydroxyisobutyric acid | HCID 11671 | — |
| Reactant | 5-(L-alaninyl)-amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one | HCID 69736335 | — |
| Product | 5-{N'-(2-hydroxy-2-methylpropionyl)-L-alaninyl}-amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6one | HCID 86592596 | — |
Reaction Steps
Following General procedure D above using 2-methyllactic acid (Aldrich) and 5-(L-alaninyl)-amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one, as described in Example 7-B, the title compound was prepared. The product was purified by flash chromatography CHCl3/MeOH (98:2) to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06906056B2 |
| Source dataset | uspto-grants-2005_06 |
| ORD ID | ord-3f3bceb9916d4f389da099fb2ad7bf89 |
| Source note | uspto-grants-2005_06 |