Phenylmethanesulfonyl chloride → HCID 86592601, compound

Participants

Reaction Steps

To 5-(L-alaninyl)-amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one (Example 7B) (0.2050 g, 0.66 mmol) in DMF (5 ml) was added benzylsulfonyl chloride (Aldrich) (0.0632 g, 0.33 mmol), stirred at RT for 3.5 days. The reaction mixture was evaporated to dryness. Water was added, extracted with CH2Cl2, washed with brine, dried over MgSO4. Evaporation and flash chromatography (silica, 5% MeOH/CH2Cl2), gave a residue, which was washed with Et2O/hexane (1:2, v/v) to give the title compound (0.0531 g, 35%) as a light yellow solid.

Provenance & Evidence