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HRID1071447

反应详情

EQUATION

反应方程式

HRID 1071447 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)N[C@H](C(=O)O)C(C(F)(F)F)C(F)(F)F
HCID26599218

未命名化合物

结构：C[C@H](N)C(=O)[C@H]1C(=O)N(C)C(N)CC2=C1C=CCC2.Cl
HCID69736556

1-(S)-[L-alaninyl]-amino-3-methyl-4,5,6,7-tetrahydro-2H-3-benzazepin-2-one hydrochloride

C14H22ClN3O2

PRODUCTS

生成物

1
结构：C[C@H](NC(=O)[C@@H](N)C(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1C(=O)N(C)C(N)CC2=C1C=CCC2
HCID131723901

未命名化合物

PROCEDURE

实验过程

Following General Procedure D above using 1-(S)-[L-alaninyl]-amino-3-methyl-4,5,6,7-tetrahydro-2H-3-benzazepin-2-one hydrochloride (Example 7-30, below) and N-Boc-hexafluorovaline (Aldrich), the protected intermediate was prepared. The Boc-group was removed using 5.0 M HCl in dioxane and the resulting free-base purified by chromatography CHCl3/MeOH (95:5) yielding the title compound as a mixture of diastereomers.

WORKUP

后处理

  1. customthe protected intermediate was prepared
  2. customThe Boc-group was removed
  3. customthe resulting free-base purified by chromatography CHCl3/MeOH (95:5)