HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Cni H1594
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3'-Aminoacetophenone | HCID 7417 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 2-Amino-4-chloro-6-methylpyrimidine | HCID 21810 | — |
| Solvent | Water | HCID 962 | — |
| Product | Cni H1594 | HCID 133110 | 78.5% |
Reaction Steps
Compound No. 15 (CNI-1594): A suspension of m-aminoacetophenone (2.7 g) and 2-amino-4-chloro-6-methyl-pyrimidine (2.87 g) in 40 mL water was treated with 1.7 mL concentrated HCl and heated at reflux for 1 hour. Addition of 40 mL 1N KOH gave a light buff solid, which was filtered out and dried to give 3.8 g 4-(3-acetylphenyl)amino-2-amino-6-methylpyrimidine, mp 196-98° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06906076B2 |
| Source dataset | uspto-grants-2005_06 |
| ORD ID | ord-dc2a60ee245d49eeb1de5883192bf981 |
| Source note | uspto-grants-2005_06 |