Ethylamine → 29526-66-7

HRID 1071511Notes

Reaction equation

HRID 1071511 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][C:3]=1[N+:11]([O-])=O.[CH2:14]([NH2:16])[CH3:15]>C(Cl)Cl>[NH2:11][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:2]=1[CH3:1])[C:6]([NH:16][CH2:14][CH3:15])=[O:7]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 663234-Methyl-3-nitrobenzoyl chloride

Product 1

HCID 1260797429526-66-7

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

4-methyl-3-nitro-benzoyl chloride (1.0 g, 5.0 mmol) was dissolved in DCM, and the solution was cooled to 0° C. Ethyl amine (2.0 M in THF, 5.0 mL, 10 mmol) was added dropwise to the acid chloride, and the reaction stirred at 0° C. for 5 min. The ice bath was removed and reaction continued to stir for 3. The solution was washed with brine, dried (Na2SO4), and concentrated in vacuo. The resulting aniline (0.75 g) was used without further purification.

Workup

  1. customThe ice bath was removed
  2. customreaction
  3. stirringto stir for 3
  4. washThe solution was washed with brine
  5. dry with materialdried (Na2SO4)
  6. concentrationconcentrated in vacuo
  7. customThe resulting aniline (0.75 g) was used without further purification

Sources & evidence

ORD record
ord-2dff38dbaa724d6d8ccc0f12cda4885a
Source dataset
uspto-grants-2005_06
Patent number
US06906067B2

Reaction notes

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