2-(Chloromethyl)-4-methylaniline hydrochloride → HCID 178488116, compound

HRID 1071542Notes

Reaction equation

HRID 1071542 reaction equation
[SH:1][C:2]1[NH:3][C:4]2[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:5]=2[N:6]=1.Cl.Cl[CH2:15][C:16]1[CH:22]=[C:21]([CH3:23])[CH:20]=[CH:19][C:17]=1[NH2:18]>>[CH3:12][O:11][C:9]1[CH:8]=[CH:7][C:5]2[NH:6][C:2]([S:1][CH2:15][C:16]3[CH:22]=[C:21]([CH3:23])[CH:20]=[CH:19][C:17]=3[NH2:18])=[N:3][C:4]=2[CH:10]=1

Participants

3

Reactant 2

HCID 223941892-(Chloromethyl)-4-methylaniline hydrochlorideHCID 178488032HCID 178488032, compound

Product 1

HCID 178488116HCID 178488116, compoundYield 41.8%

Procedure

The title compound (1.95 g) was prepared by the method of Example 1 using 2.81 g of 2-mercapto-5-methoxybenzimidazole instead of 2-mercaptobenzimidazole and 3.00 g of 2-(chloromethyl)-4-methylaniline hydrochloride instead of 2-(chloromethyl)-N,N-dimethylaniline. Analysis. Calc'd. for C16H17N3OS: C, 64.19; H, 5.72; N, 14.04; S, 10.71. Found: C, 63.71; H, 5.80; N, 13.86; S, 10.60.

Sources & evidence

ORD record
ord-994312c0e8b647b99225167fad3aebfc
Source dataset
uspto-grants-2005_06
Patent number
US06906078B2

Reaction notes

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