反应详情

The title compound was prepared by the method of Example 1 using 2.50 g of 2-mercapto-5-chlorobenzimidazole instead of 2-mercaptobenzimidazole and 2.42 g of 2-(chloromethyl)aniline hydrochloride instead of 2-(chloromethyl)-N,N-dimethylaniline. The basic extraction used 5% sodium hydroxide instead of sodium carbonate. Washing the solid residue from the dichloromethane extract with additional dichloromethane gave 2.47 g of the title compound. Analysis. Calc'd. for C14H12N3ClS: C, 58.03; H, 4.17; N, 14.10; S, 11.06; C1, 12.23. Found: C, 57.33; H, 4.06; N, 14.27; S, 10.99; C1, 12.74.

1. extractionThe basic extraction
2. washWashing the solid residue from the dichloromethane
3. extractionextract with additional dichloromethane