P-Anisidine → Benzamide

HRID 1071592Notes

Reaction equation

HRID 1071592 reaction equation
COC1C=CC(N)=CC=1.N[C:11]1[CH:12]=[C:13]([CH:25]=[CH:26][C:27]=1OC)[C:14]([NH:16]C1C=CC(F)=C(F)C=1)=[O:15]>>[C:14]([NH2:16])(=[O:15])[C:13]1[CH:25]=[CH:26][CH:27]=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 7732P-AnisidineHCID 10755041HCID 10755041, compound

Product 1

HCID 2331BenzamideYield 56.3%

Procedure

The title compound was synthesized as in Example 1 using p-anisidine (1.0 g, 7.1 mmol), CSI (0.85 mL, 9.8 mmol), and 3-amino-N-(3,4-difluoro-phenyl)-4-methoxy-benzamide (1.75 g, 6.3 mmol) to give 0.43 g of benzamide, N-(3,4-difluorophenyl)-4-methoxy-3-[[[[[(4-methoxyphenyl)amino]-carbonyl]amino]sulfonyl]amino]-. Microanalysis: C22H20F2N4O6S; calculated: C=52.17; H=3.98; N=11.06. found: C=52.17; H=3.89; N=10.95. Mp 189-192° C.

Sources & evidence

ORD record
ord-e20c99807d2b4d91a40fb64611e937b0
Source dataset
uspto-grants-2005_06
Patent number
US06906094B2

Reaction notes

Loading…