4-Chloroaniline → Benzamide

Participants

Reaction Steps

The title compound was synthesized as in Example 1 using 4-chloroaniline (1.0 g, 8.1 mmol), CSI (0.85 mL, 9.8 mmol), and 3-amino-N-(3,4-difluoro-phenyl)-4-methoxy-benzamide (1.17 g, 4.2 mmol) to give 0.24 g of benzamide, 3-[[[[[(4-chlorophenyl)amino]carbonyl]amino]sulfonyl]amino]-N-(3,4-difluorophenyl)-4-methoxy-. Microanalysis: C21H17ClF2N4O5S; calculated: C=49.37; H=3.35; N=10.97. found: C=49.15; H=3.17; N=10.70. MS: M++1=511 Da. Mp 195-198° C.

Provenance & Evidence