HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1071597Generated: November 1, 2026
Oxindole → 3-[(3-Methyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one
https://huagongshe.com/reaction/1071597
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Oxindole | HCID 321710 | — |
| Reactant | 3-methyl-1H-pyrrole-2-carbaldehyde | HCID 11423566 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-[(3-Methyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one | HCID 60044235 | 67.4% |
Reaction Steps
A reaction mixture of 133.0 mg of oxindole, 130.9 mg of the 3-methylpyrrole-2-carboxaldehyde, and 3 drops of piperidine in 2 mL of ethanol was stirred at 90° C. for 3 h. After cooling, the precipitate was filtered, washed with cold ethanol, and dried to yield 150.9 mg (67%) of the title compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06906093B2 |
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| Source dataset | uspto-grants-2005_06 |
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| ORD ID | ord-2fb3b93e18454c7c86d87f3dfa876f9e |
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| Source note | uspto-grants-2005_06 |
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