4-Cyano-4-(3-cyano-5-thienyl)-5-methylhexanol → (4-Cyano-4-(3-cyano-5-thienyl)-5-methylhexyl]-4-[2-(3-cyanophenoxy)ethyl]piperazine
Reaction equation
[C:1]([C:3]([C:11]1[S:15][CH:14]=[C:13]([C:16]#[N:17])[CH:12]=1)([CH:8]([CH3:10])[CH3:9])[CH2:4][CH2:5][CH2:6]O)#[N:2].[C:18]([C:20]1[CH:21]=[C:22]([CH:32]=[CH:33][CH:34]=1)[O:23][CH2:24][CH2:25][N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)#[N:19]>>[C:1]([C:3]([C:11]1[S:15][CH:14]=[C:13]([C:16]#[N:17])[CH:12]=1)([CH:8]([CH3:10])[CH3:9])[CH2:4][CH2:5][CH2:6][N:29]1[CH2:28][CH2:27][N:26]([CH2:25][CH2:24][O:23][C:22]2[CH:32]=[CH:33][CH:34]=[C:20]([C:18]#[N:19])[CH:21]=2)[CH2:31][CH2:30]1)#[N:2]Participants
3
Procedure
The title compound was obtained as a pale yellow oil (0.15 g, 58%) from 4-cyano-4-(3-cyano-5-thienyl)-5-methylhexanol and 1-[2-(3-cyanophenoxy)ethyl]piperazine in the same manner as in Example 68.
Sources & evidence
- ORD record
- ord-4a16d97d25ed4941a27343370e0a3eb8
- Source dataset
- uspto-grants-2005_06
- Patent number
- US06906072B1
Reaction notes
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