Iodide Ion → 1-[4-Cyano-4-(2-thienyl)-5-methylhexyl]-(3S)-3-[N-(2-cyanoethyl)-N-benzylamino]pyrrolidine
Reaction equation
[C:1]([C:3]([C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)([CH:8]([CH3:10])[CH3:9])[CH2:4][CH2:5][CH2:6]I)#[N:2].[I-].[C:17]([CH2:19][CH2:20][N:21]([C@H:29]1[CH2:33][CH2:32][NH:31][CH2:30]1)[CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)#[N:18]>>[C:1]([C:3]([C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)([CH:8]([CH3:10])[CH3:9])[CH2:4][CH2:5][CH2:6][N:31]1[CH2:32][CH2:33][C@H:29]([N:21]([CH2:20][CH2:19][C:17]#[N:18])[CH2:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:30]1)#[N:2]Participants
4
Procedure
Optically active body, 4-cyano-4-(2-thienyl)-5-methylhexyl iodide (iodide D (optically active body)) was synthesized from the alcohol A in accordance with Example 77 (1). The title compound was synthesized in accordance with Example 75 from the iodide D and (3S)-3-[N-(2-cyanoethyl)-N-benzylamino]pyrrolidine of “Synthetic method A” (1) (1) of Example 175. The physico-chemical data of the title compound was as below.
Sources & evidence
- ORD record
- ord-5417dd0a50ca47bfaf7f5317bd240870
- Source dataset
- uspto-grants-2005_06
- Patent number
- US06906072B1
Reaction notes
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