α-(3-Iodopropyl)-α-(1-methylethyl)-2-thiopheneacetonitrile → 1-[4-Cyano-4-(2-thienyl)-5-methylhexyl]-4-[2-(5-chloro-3-pyridyloxy)ethyl]piperidine

HRID 1071658Notes

Reaction equation

HRID 1071658 reaction equation
[C:1]([C:3]([C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)([CH:8]([CH3:10])[CH3:9])[CH2:4][CH2:5][CH2:6]I)#[N:2].[Cl:16][C:17]1[CH:18]=[C:19]([O:23][CH2:24][CH2:25][CH:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[CH:20]=[N:21][CH:22]=1>>[C:1]([C:3]([C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)([CH:8]([CH3:10])[CH3:9])[CH2:4][CH2:5][CH2:6][N:29]1[CH2:28][CH2:27][CH:26]([CH2:25][CH2:24][O:23][C:19]2[CH:20]=[N:21][CH:22]=[C:17]([Cl:16])[CH:18]=2)[CH2:31][CH2:30]1)#[N:2]

Participants

3

Reactant 2

HCID 22393563α-(3-Iodopropyl)-α-(1-methylethyl)-2-thiopheneacetonitrileHCID 223936094-[2-(5-Chloro-3-pyridyloxy)ethyl]piperidine

Product 1

HCID 223937761-[4-Cyano-4-(2-thienyl)-5-methylhexyl]-4-[2-(5-chloro-3-pyridyloxy)ethyl]piperidine

Procedure

The title compound was synthesized in accordance with Example 75 from 4-cyano-4-(2-thienyl)-5-methylhexyl iodide and 4-[2-(5-chloro-3-pyridyloxy)ethyl]piperidine. The physico-chemical data of the compound was as below.

Sources & evidence

ORD record
ord-145eec1eb7c94c5b8d8bdda2a3356e99
Source dataset
uspto-grants-2005_06
Patent number
US06906072B1

Reaction notes

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