HCID 20801194, compound → HCID 20801167, compound

HRID 1071682Notes

Reaction equation

HRID 1071682 reaction equation
C([O:3][C:4](=[O:43])[CH2:5][N:6]([C:16]([C:18]1[N:19]([CH2:31][C:32]2[CH:36]=[C:35]([C:37]3[S:38][C:39]([Cl:42])=[CH:40][CH:41]=3)[O:34][N:33]=2)[C:20]2[C:25]([CH:26]=1)=[C:24]([C:27]([F:30])([F:29])[F:28])[CH:23]=[CH:22][CH:21]=2)=[O:17])[CH:7]1[CH2:12][CH2:11][N:10]([CH:13]([CH3:15])[CH3:14])[CH2:9][CH2:8]1)C.C(OC(=O)CN(C(C1N(CC2C=C(C3SC(Cl)=CC=3)ON=2)C2C(C=1)=CC=CC=2C)=O)C1CCN(C(C)C)CC1)C>>[Cl:42][C:39]1[S:38][C:37]([C:35]2[O:34][N:33]=[C:32]([CH2:31][N:19]3[C:20]4[C:25](=[C:24]([C:27]([F:30])([F:28])[F:29])[CH:23]=[CH:22][CH:21]=4)[CH:26]=[C:18]3[C:16]([N:6]([CH2:5][C:4]([OH:43])=[O:3])[CH:7]3[CH2:8][CH2:9][N:10]([CH:13]([CH3:15])[CH3:14])[CH2:11][CH2:12]3)=[O:17])[CH:36]=2)=[CH:41][CH:40]=1

Participants

3

Reactant 2

HCID 20801194HCID 20801194, compoundHCID 20801195HCID 20801195, compound

Product 1

HCID 20801167HCID 20801167, compound

Procedure

The title compound was prepared analogously to example 185 with the difference that [{1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-4-trifluoromethyl-1H-indole-2-carbonyl}-(1-isopropyl-piperidin-4-yl)-amino]-acetic acid ethyl ester was used instead [{1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-7-methyl-1H-indole-2-carbonyl}-(1-isopropyl-piperidin-4-yl)-amino]-acetic acid ethyl ester. MS (ESI+): m/e=609, chloro pattern.

Sources & evidence

ORD record
ord-62edb5d67c774aa9bab06e8f61b15d8e
Source dataset
uspto-grants-2005_06
Patent number
US06906084B2

Reaction notes

Loading…