HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → n-{[4-(1,3-Dioxobenzo[c]azolidin-2-yl)phenyl]sulfonyl}(phenylamino)carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Phenylsulphonyl isocyanate | HCID 76096 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 4-(1,3-Dioxo-1,3-dihydro-isoindol-2-YL)-benzenesulfonamide | HCID 3586494 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | n-{[4-(1,3-Dioxobenzo[c]azolidin-2-yl)phenyl]sulfonyl}(phenylamino)carboxamide | HCID 22064432 | 100% |
Reaction Steps
To a solution of 4-(1,3-dioxobenzo[c]azolidin-2-yl)benzenesulfonamide in 660 uL of DMSO was added 60 mg (0.40 mmol) of DBU followed by 36 μl (0.33 mmol) of phenylsulfonylisocyanate. After stirring for 0.5 h, the mixture was poured into 1N HCl, cooled, and the precipitate was collected by filtration and dried under vacuum to give 137 mg (100%) of the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06906063B2 |
| Source dataset | uspto-grants-2005_06 |
| ORD ID | ord-1da98bce67514b27becd9b5f1a300e86 |
| Source note | uspto-grants-2005_06 |