Trifluoroacetic acid → 6-Chloro-4-oxo-1,2,3,4-tetrahydrocarbazole

Participants

Reaction Conditions

Reaction Steps

A mixture of cyclohexane-1,3-dione mono-(4-chlorophenyl) hydrazone (45 mmol) obtained in Example 131 and trifluoroacetic acid (30 mL) is heated to 80° C. for 16 h, cooled to room temperature, poured over ice water and filtered. The filtercake is dried and recrystallized from ethanol/water to afford the title product, 4.2 g (42% yield), identified by HPLC and mass spectral analyses.

Provenance & Evidence