Tetrabutylammonium Fluoride → HCID 20802592, compound

Participants

Reaction Conditions

Reaction Steps

1.95 g (4.22 mmol) of 3-t-butyl dimethylsilyloxy-4-((4-ethylphenyl)methyl)-1-(1,3-difluoro-2-propyl)-5-(trifluoromethyl)pyrazole was added to 30 ml of tetrahydrofuran and cooled to 0° C. To the thus obtained mixture, 6.33 ml (6.33 mmol) of a 1M tetrahydrofuran solution of tetrabutylammonium fluoride was slowly added, and the obtained reaction mixture was stirred at room temperature for 30 minutes. The reaction mixture was concentrated and purified with a silica gel column using a mixed solvent of ethyl acetate and hexane at a ratio of 1:4. Thus, 684 mg (1.96 mmol) of the intended product was obtained. (46% yield)

Provenance & Evidence