Sodium Carbonate → HCID 22390458, compound

Participants

Reaction Steps

19.7 g of 4-acetyl-2-chlorophenyl trifluoromethanesulphonate (compound Va.1), 10 g of 4-fluorobenzeneboronic acid, 2 g of tetrakis(triphenylphosphine)palladium, 17.9 g of sodium carbonate in 84.5 ml of water, 591 ml of toluene, 200 ml of ethanol and 5.51 g of lithium chloride are stirred under an inert atmosphere at 60° C. for 8 hours. The reaction mixture is then stirred for 12 hours at room temperature. The resulting mixture is filtered and the solvents are evaporated from the filtrate under reduced pressure. The residue obtained is purified by chromatography on a column of silica gel, eluting with a 97/3 (v/v) cyclohexane/ethyl acetate mixture; yield=94%.

Provenance & Evidence