Diethyl Ether → HCID 22390462, compound

Participants

Reaction Conditions

Reaction Steps

5.6 ml of a 15% solution of n-butyllithium in hexane are added, at −78° C., to 3.1 g of 1-[3-(4-bromo-3-chlorophenyl)prop-2-ynyl]azepane (compound Ia.7) in 50 ml of diethyl ether and stirring is maintained at −75° C. for 1 hour. Still at −78° C., 1.38 g of 2-amandatanone in 25 ml of diethyl ether are added, and the reaction mixture is then stirred for 1 hour at −78° C.

Provenance & Evidence