Trifluoromethanesulfonic anhydride → HCID 22390454, compound

Participants

Reaction Steps

8.2 ml of triflic anhydride are added at 5° C. to 9.7 g of 2-chloro-4-(4,4-dimethylcyclohexyl)phenol (compound IX.1) in 60 ml of pyridine, the reaction mixture is left to stand for 30 minutes at 0° C., and then the reaction mixture is stirred at room temperature for 12 hours. The reaction mixture is hydrolysed and then extracted with dichloromethane. The organic phase is dried over magnesium sulphate and the solvents are evaporated off under reduced pressure. The residue obtained is taken up in toluene, and then the solvents are evaporated off under reduced pressure. The residue obtained is purified by chromatography on a column of silica gel, eluting with a cyclohexane/ethyl acetate mixture which varies from 100/0 to 99/1 (v/v). 15 g of the compound are obtained.

Provenance & Evidence