2-[4-(2-Azidoethyl)phenyl]-1H-imidazole → 2-[4-(1H-Imidazol-2-yl)phenyl]ethan-1-amine

Participants

Reaction Steps

To a solution of 2-[4-(2-azidoethyl)phenyl]-1H-imidazole (120 mg, 0.56 mmol) in EtOH, Pd/C (6 mg, 0.06 mmol) was added. A hydrogen balloon was placed over the reaction and the reaction was complete after approximately five hours. Reaction mixture was filtered through a pad of celite and concentrated to give 2-[4-(1H-imidazol-2-yl)phenyl]ethanamine which was used without further purification. LCMS (ES) m/z 188.4 (M+H)+.

Provenance & Evidence