HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 1-Benzyl-5-bromoazepan-4-one hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 1-Benzylazepan-4-one hydrochloride | HCID 13072029 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1-Benzyl-5-bromoazepan-4-one hydrobromide | HCID 22390903 | — |
Reaction Steps
175 g of (0.732 mol) 1-benzylhexahydroazepin-4-one hydrochloride IV are dissolved in 500 mL acetic acid. Upon addition of 100 mL of a saturated solution (30%) of hydrobromic acid in acetic acid, 37 mL (0.732 mol) of bromine are added dropwise at room temperature and with efficient stirring, whereby the brown color of bromine disappears.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06908926B1 |
| Source dataset | uspto-grants-2005_06 |
| ORD ID | ord-73ab4486d02940f9b8bc136e934a56a2 |
| Source note | uspto-grants-2005_06 |