Methyl iodide → HCID 44307960, compound

HRID 1072007Notes

Reaction equation

HRID 1072007 reaction equation
[CH3:1][N:2]([CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[CH2:15][N:16]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[N:18]=[N:17]1)[CH3:3].[CH3:25][I:26]>CC(C)=O>[I-:26].[N:16]1([CH2:15][C:7]2[N:6]([CH2:5][CH2:4][N+:2]([CH3:25])([CH3:1])[CH3:3])[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[N:8]=2)[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[N:18]=[N:17]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 5271993HCID 5271993, compound

Product 1

HCID 44307960HCID 44307960, compoundYield 14%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The free base of 1-[1-(N,N-dimethyl-aminoethyl)-1H-benzimidazol-2-ylmethyl]-1H-benzotriazole (100 mg, 0.312 mmol) was dissolved in anhydrous acetone. Methyl iodide (44 mg, 0.312 mmol) was added with stirring under N2 at room temperature. After 3 hours, the white solid was filtered and dried under vacuum to give 19.5 mg (14%) of the title compound as a white solid.

Workup

  1. filtrationthe white solid was filtered
  2. customdried under vacuum

Sources & evidence

ORD record
ord-df80e786b11f4ddb87eb0007a314c631
Source dataset
uspto-grants-2005_06
Patent number
US06908936B2

Reaction notes

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