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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1072035Erstellt: 26. Oktober 2026

2-Amino-4-methylpyridine → 2-(4'-Chloropropoxy-3'-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine hydrobromide

https://huagongshe.com/reaction/1072035

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt2-Amino-4-methylpyridineHCID 1533—
Eduktalpha-Bromo-3'-methoxy-4'-chloropropoxyacetophenoneHCID 22015629—
LösungsmittelEthanolHCID 702—
Produkt2-(4'-Chloropropoxy-3'-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine hydrobromideHCID 2201559870,5%

Reaktionsschritte

A solution of the product of Step B (1.44 g) and 2-amino-4-picoline (0.486 g) in ethanol (6 mL) was heated at 73° C. for 1 hour. The reaction mixture was cooled to ambient temperature and evaporated to a yellow solid. The solid was stirred with 25 mL of dichloromethane for approximately 10 minutes. The mixture was filtered and the solid product collected to yield the title compound (1.3 g).

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS06908929B2
Quelldatensatzuspto-grants-2005_06
ORD IDord-c237723774134c6fa3713115b59323df
Quellennotizuspto-grants-2005_06