反应详情

A mixture of 1-[(2S,3R)-2-(benzyloxy)-5-(2-(methylthio)phenyl)-3-pentyl]imidazole-4-carboxamide (133 mg) and iodotrimethylsilane (0.16 ml) in chloroform (5 ml) was stirred at room temperature for 2 hours. The mixture was poured into cold methanol and the whole was evaporated in vacuo. The residue was taken up in ethyl acetate, washed with water, aqueous sodium bisulfite and sodium bicarbonate, successively, and dried. The residue left after evaporation of solvent was purified by column chromatography on silica gel, eluting with a mixture of dichloromethane and methanol (20:1) to give a white powder of 1-[(2S,3R)-2-hydroxy-5-(2-(methylthio)phenyl)-3-pentyl]imidazole-4-carboxamide (2) (62 mg).

1. customthe whole was evaporated in vacuo
2. washwashed with water, aqueous sodium bisulfite and sodium bicarbonate
3. customsuccessively, and dried
4. waitThe residue left
5. customafter evaporation of solvent
6. customwas purified by column chromatography on silica gel
7. washeluting with a mixture of dichloromethane and methanol (20:1)