HCID 22390510, compound → HCID 10116050, compound

Participants

Reaction Steps

A solution of [5-(1,4-dioxa-8-aza-spiro[4.5]dec-8-ylmethyl)-pyrrolo[2,1-f][1,2,4]triazin-4-yl]-[1-(3-fluoro-benzyl)-1H-indazol-5-yl]-amine (54 mg, 0.105 mmole) in a mixture of THF (1 mL) and 1 N aq. HCl (1 mL) containing 16 drops of conc. HCl was left stirring a RT for 7 days. The reaction was diluted with DCM and neutralized with sat. aq. NaHCO3 solution. After drying (Na2SO4), the solvent was removed to leave the title compound as an oil (19 mg, 39%). MS: 488 (M+H2O+H)+; HPLC Ret Time: 2.35 min (YMC Xterra ODS S7 C18, 3.0×50 mm column, 5 min gradient (component B was varied from 20 to 60%), 5 mL/min).

Provenance & Evidence