1-Benzyl-1H-indol-5-ylamine → 5-[4-(1-Benzyl-1H-indol-5-ylamino)-6-oxo-6,7-dihydro-pyrrolo[2,3-D]pyrimidin-5-ylidenemethyl]-4-methyl-1H-pyrrole-2-carboxylic acid (2-morpholin-4-YL-ethyl)-amide hydrochloride

Participants

Reaction Steps

The title compound (8% yield) was prepared from 5-(4-chloro-6-oxo-6,7-dihydro-pyrrolo[2,3-d]pyrimidin-5-ylidenemethyl)-4-methyl-1H-pyrrole-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide and 1-benzyl-1H-indol-5-ylamine according to the procedure described for Example 12. 1H NMR (360 MHz, DMSO-d6) δ 13.44 (br s, 1H, NH), 11.79 (br s, 1H, NH), 10.97 (br s, 1H, HCl), 9.28 (br s, 1H), 8.85 (br s, 1H, CONHCH2), 8.25 (s, 1H, H-vinyl), 7.1-7.5 (m, 10H), 6.89 (br s, 1H), 6.43 (s, 1H), 5.40 (s, 2H), 3.96 (m, 2H, CH2), 3.84 (m, 2H, CH2), 3.68 (m, 2H, CH2), 3.52 (m, 2H, CH2), 3.29 (m, 2H, CH2), 3.12 (m, 2H, CH2), 2.53 (s, 3H, CH3).

Provenance & Evidence