5-Methyl-1H-imidazole-4-carbaldehyde → HCID 178433258, compound

HRID 1072141Notes

Reaction equation

HRID 1072141 reaction equation
[Cl:1][C:2]1[C:3]2[CH2:10][C:9](=[O:11])[NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[CH3:12][C:13]1[N:17]=[CH:16][NH:15][C:14]=1[CH:18]=O>>[Cl:1][C:2]1[C:3]2[C:10](=[CH:18][C:14]3[NH:15][CH:16]=[N:17][C:13]=3[CH3:12])[C:9](=[O:11])[NH:8][C:4]=2[N:5]=[CH:6][N:7]=1

Participants

3

Reactant 2

HCID 27958875-Methyl-1H-imidazole-4-carbaldehydeHCID 120958704-chloro-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one

Product 1

HCID 178433258HCID 178433258, compoundYield 76.9%

Procedure

4-Chloro-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one (1 eq.) was condensed with 5-methyl-3H-imidazole-4-carbaldehyde (1 eq.) at room temperature to give (76.9%) of 4-chloro-5-(5-methyl-3H-imidazol-4-ylmethylene)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one.

Sources & evidence

ORD record
ord-0bcbd3c6254b4e2da2a8b38275596c4e
Source dataset
uspto-grants-2005_06
Patent number
US06908930B2

Reaction notes

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