4-(3-Chloro 4-fluoro-phenylamino)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one → HCID 69799154, compound

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Reaction Steps

4-(3-Chloro-4-fluoro-phenylamino)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one was condensed with 3-methyl-5-(3,4,5-trimethyl-piperazine-1-carbonyl)-1H-pyrrole-2-carbaldehyde to give the title compound. 1H NMR (360 MHz, DMSO-d6) δ 13.41 (br s, 1H, NH), 11.78 (br s, 1H, NH), 9.23 (br s, 1H), 8.33 (s, 1H), 7.72 (dd, J=2.5 & 6.5 Hz, 1H), 7.43 (m, 1H), 7.33-7.38 (m, 2H), 6.58 (m, 1H), 4.19 (m, 2H, CH2), 2.78 (m, 2H), 2.23 (s, 3H, CH3), 2.18 (s, 3H, CH3), 2.11 (m, 2H), 1.06 (d, J=6.6 Hz, 6H, 2×CH3). MS 524 [M++1].

Provenance & Evidence