7-Iodoimidazo[5,1-B]thiazole → HCID 69363209, compound

HRID 1072327Notes

Reaction equation

HRID 1072327 reaction equation
I[C:2]1[N:3]=[CH:4][N:5]2[CH:9]=[CH:8][S:7][C:6]=12.[N+:10]([C:13]1[CH:29]=[CH:28][C:16]([CH2:17][O:18][C:19]([N:21]2[CH2:25][CH2:24][CH2:23][C@H:22]2[CH:26]=[O:27])=[O:20])=[CH:15][CH:14]=1)([O-:12])=[O:11]>>[N+:10]([C:13]1[CH:29]=[CH:28][C:16]([CH2:17][O:18][C:19]([N:21]2[CH2:25][CH2:24][CH2:23][C@H:22]2[CH:26]([OH:27])[C:2]2[N:3]=[CH:4][N:5]3[CH:9]=[CH:8][S:7][C:6]=23)=[O:20])=[CH:15][CH:14]=1)([O-:12])=[O:11]

Participants

3

Reactant 2

HCID 177737777-Iodoimidazo[5,1-B]thiazoleHCID 20802794HCID 20802794, compound

Product 1

HCID 69363209HCID 69363209, compoundYield 65.9%

Procedure

7-[[(2S)-1-(4-Nitrobenzyloxycarbonyl)pyrrolidin-2-yl]hydroxymethyl]imidazo[5,1-b]thiazole (2.21 g) was prepared in the same manner as in step a) of Synthesis Example 1, except that 2.50 g of 7-iodoimidazo[5,1-b]thiazole and 2.32 g of (2S)-1-(4-nitrobenzyloxycarbonyl)pyrrolidine-2-aldehyde were used as the starting compounds.

Workup

  1. customof Synthesis Example 1

Sources & evidence

ORD record
ord-3966e813ca01483e833ce79e44de7e55
Source dataset
uspto-grants-2005_06
Patent number
US06908913B2

Reaction notes

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