Tributyltin Chloride → HCID 22390285, compound

HRID 1072334Notes

Reaction equation

[CH3:1][C:2]1[N:7]=[CH:6][C:5]([C:8]([C:10]2[N:11]=[CH:12][N:13]3[CH:17]=[CH:16][S:15][C:14]=23)=[O:9])=[CH:4][CH:3]=1.[CH2:18]([Sn:22](Cl)([CH2:27][CH2:28][CH2:29][CH3:30])[CH2:23][CH2:24][CH2:25][CH3:26])[CH2:19][CH2:20][CH3:21].C[Si]([N-][Si](C)(C)C)(C)C.[Li+].C1COCC1>>[CH3:1][C:2]1[N:7]=[CH:6][C:5]([C:8]([C:10]2[N:11]=[CH:12][N:13]3[CH:17]=[C:16]([Sn:22]([CH2:23][CH2:24][CH2:25][CH3:26])([CH2:27][CH2:28][CH2:29][CH3:30])[CH2:18][CH2:19][CH2:20][CH3:21])[S:15][C:14]=23)=[O:9])=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 15096Tributyltin Chloride

HCID 22390402HCID 22390402, compound

HCID 23714775LiHMDS tetrahydrofuran

Product 1

HCID 22390285HCID 22390285, compound

Procedure

The title compound (606 mg) was prepared in substantially the same manner as in step c) of Synthesis Example 1, except that 447 mg of 7-(6-methylpyridin-3-yl)carbonylimidazo[5,1-b]thiazole, 0.552 ml of tri-n-butylstannyl chloride, and 3.2 ml of a 1.0 N lithium bis(trimethylsilyl)amide/THF solution were used as the starting materials.

Workup

customof Synthesis Example 1

Sources & evidence

ORD record: ord-500c3418adc342ba9decf563a990b63c
Source dataset: uspto-grants-2005_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06908913B2

Reaction notes

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