1,3-Thiazole-5-carbaldehyde → 7-(Thiazol-5-yl)carbonylimidazo[5,1-b]thiazole

HRID 1072342Notes

Reaction equation

HRID 1072342 reaction equation
I[C:2]1[N:3]=[CH:4][N:5]2[CH:9]=[CH:8][S:7][C:6]=12.[S:10]1[C:14]([CH:15]=[O:16])=[CH:13][N:12]=[CH:11]1>>[S:10]1[C:14]([C:15]([C:2]2[N:3]=[CH:4][N:5]3[CH:9]=[CH:8][S:7][C:6]=23)=[O:16])=[CH:13][N:12]=[CH:11]1

Participants

3

Reactant 2

HCID 27735771,3-Thiazole-5-carbaldehydeHCID 177737777-Iodoimidazo[5,1-B]thiazole

Product 1

HCID 223903387-(Thiazol-5-yl)carbonylimidazo[5,1-b]thiazoleYield 75.6%

Procedure

7-(Thiazol-5-yl)carbonylimidazo[5,1-b]thiazole (187 mg) was prepared in the same manner as in step a) of Synthesis Example 3, except that 265 mg of 7-iodoimidazo[5,1-b]thiazole and 119 mg of thiazole-5-aldehyde were used as the starting compounds.

Workup

  1. customof Synthesis Example 3

Sources & evidence

ORD record
ord-affcdc2e17dc4fb0a6894ddef32502cd
Source dataset
uspto-grants-2005_06
Patent number
US06908913B2

Reaction notes

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